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23076-35-9, Xylazine hydrochloride

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CAS No:23076-35-9
Other Names:Xylazine HCl
MF:C12H17ClN2S
EINECS No:245-417-0
Place of Origin:China
Type:Pharmaceutical Intermediates
Purity:99%
Brand Name:DUMI
Model Number:23076-35-9
Application:Animal Pharmaceuticals
Appearance:White Powder
Density:1.15 g/cm3
Molecular Weight:256.795
Accurate Mass:256.080109
Logarithmic:3.51880
Storage:A Cool And Dry Place
Stability:Stable At Room Temperature And Pressure


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Use of Xylazine hydrochloride
Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.Target: Adrenergic ReceptorXylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence). We concluded that xylazine given by epidural injection results in safe, effective perineal analgesia in horses [2].

Xylazine hydrochloride Biological Activity

Description Xylazine Hydrochloride is α2 class of adrenergic receptor agonist.Target: Adrenergic ReceptorXylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence). We concluded that xylazine given by epidural injection results in safe, effective perineal analgesia in horses [2].
Related Catalog
References [1]. Reyes, J.C., et al., The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico. J Urban Health, 2012. 89(3): p. 519-26.[2]. Hsu, W.H., Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents. J Pharmacol Exp Ther, 1981. 218(1): p. 188-92.

Chemical & Physical Properties

Density 1.15g/cm3
Boiling Point 334.2ºC at 760mmHg
Melting Point 150-164?C (dec.)
Molecular Formula C12H17ClN2S
Molecular Weight 256.795
Flash Point 155.9ºC
Exact Mass 256.080109
PSA 49.69000
LogP 3.51880
Vapour Pressure 0.00013mmHg at 25°C
Storage condition −20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ0776350
CHEMICAL NAME :
4H-1,3-Thiazine, 5,6-dihydro-2-(2,6-xylidino)-, monohydrochloride
CAS REGISTRY NUMBER :
23076-35-9
LAST UPDATED :
199609
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C12-H16-N2-S.Cl-H
MOLECULAR WEIGHT :
256.82
WISWESSER LINE NOTATION :
T6N CS AUTJ BMR B1 F1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human – man
DOSE/DURATION :
14 mg/kg
TOXIC EFFECTS :
Behavioral – coma Cardiac – EKG changes not diagnostic of specified effects Lungs, Thorax, or Respiration – other changes
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 15,281,1979
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
109 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ZYYZEW Zhongguo Yaolixue Yu Dulixue Zazhi. (Chinese Pharmacological Society, 27 Tai-Ping Road, Beijing 100850, China) V.1- 1986- Volume(issue)/page/year: 9,96,1995
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Mammal – dog
DOSE/DURATION :
47 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 15,281,1979
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent – guinea pig
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977- Volume(issue)/page/year: 24,410,1982

Synonyms

BAY 1470 hydrochloride
Xylazine chloride
2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine hydrochloride
2-[(2,6-Dimethylphenyl)amino]-5,6-dihydro-4H-1,3-thiazine Hydrochloride
N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine hydrochloride (1:1)
BAY VA 1470
EINECS 245-417-0
4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-, hydrochloride (1:1)
Celactal
N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine hydrochloride
Xylazine HCl
MFCD00058196

 

 

 

 





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