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527-73-1, 2-Nitroimidazole

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2-Nitroimidazole Biological Activity

Description Azomycin is an antibiotic which can be active against aerobic Gram-positive and Gram-negative bacteria.
Related Catalog
Target Bacterial[1]
In Vitro Azomycin is an antibiotic which can be active against aerobic Gram-positive and Gram-negative bacteria. It is found that Azomycin is also active against a variety of anaerobic bacteria[1].
References [1]. Shoji JH, et al. Isolation of azomycin from Pseudomonas fluorescens. J Antibiot (Tokyo). 1989 Oct;42(10):1513-4.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 373.6±25.0 °C at 760 mmHg
Melting Point 287 °C (dec.)(lit.)
Molecular Formula C3H3N3O2
Molecular Weight 113.075
Flash Point 179.7±23.2 °C
Exact Mass 113.022530
PSA 74.50000
LogP 0.15
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.612
Storage condition Refrigerator
Water Solubility insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NI7875000
CHEMICAL NAME :
Imidazole, 2-nitro-
CAS REGISTRY NUMBER :
527-73-1
BEILSTEIN REFERENCE NO. :
0116444
LAST UPDATED :
199701
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C3-H3-N3-O2
MOLECULAR WEIGHT :
113.09
WISWESSER LINE NOTATION :
T5M CNJ BNW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
316 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
80 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Microorganism – not otherwise specified
DOSE/DURATION :
1 mg/plate
REFERENCE :
JGAMA9 Journal of General and Applied Microbiology. (Microbiology Research Foundation, c/o Japan Academic Soc. Center Bldg., 2-4-16 Yayoi, Bunkyo-ku, Tokyo, 113, Japan) V.1- 1955- Volume(issue)/page/year: 11,129,1965 *** REVIEWS *** TOXICOLOGY REVIEW ADCMAZ Advances in Chemotherapy. (New York, NY) V.1-3, 1964-68. For publisher information, see AVPCAQ. Volume(issue)/page/year: 3,39,1968 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – X6614 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 1822 (estimated) No. of Female Employees: 272 (estimated)

 Synonyms

2-Nitroimidazol
Azomycin
2-Nitro-1H-imidazole
MFCD00005185
2-Nitroimidazole
EINECS 208-425-5
1H-Imidazole, 2-nitro-

 

 

 


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