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6080-56-4, lead diacetate trihydrate

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Chemical & Physical Properties

Density 2,55 g/cm3
Boiling Point 280°C
Melting Point 75 °C (dec.)(lit.)
Molecular Formula C4H12O7Pb
Molecular Weight 379.33400
Flash Point 40ºC
Exact Mass 380.03500
PSA 80.29000
Water Solubility 625 g/L
:
200 mg/kg
TOXIC EFFECTS :
Blood – other changes
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
174 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo – Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent – guinea pig
DOSE/DURATION :
2100 mg/kg
TOXIC EFFECTS :
Behavioral – somnolence (general depressed activity) Behavioral – coma Gastrointestinal – hypermotility, diarrhea
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
3750 mg/kg/15D-C
TOXIC EFFECTS :
Nutritional and Gross Metabolic – weight loss or decreased weight gain
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
250 mg/kg/5W-I
TOXIC EFFECTS :
Vascular – BP lowering not characterized in autonomic section
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
40 gm/kg/12W-C
TOXIC EFFECTS :
Brain and Coverings – other degenerative changes Biochemical – Enzyme inhibition, induction, or change in blood or tissue levels – true cholinesterase Biochemical – Neurotransmitters or modulators (putative) – catecholamine levels in CNS
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
875 mg/kg/14D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder – other changes in urine composition Liver – other changes Biochemical – Enzyme inhibition, induction, or change in blood or tissue levels – other Enzymes
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
681 mg/kg/7D-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder – other changes in urine composition Blood – other changes Biochemical – Enzyme inhibition, induction, or change in blood or tissue levels – dehydrogenases
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
8524 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic – Carcinogenic by RTECS criteria Kidney, Ureter, Bladder – Kidney tumors Reproductive – Tumorigenic effects – testicular tumors
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2219 mg/kg
SEX/DURATION :
lactating female 18 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – behavioral
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1611 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception lactating female 17 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – behavioral
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
49780 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception lactating female 17 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – delayed effects
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1593 mg/kg
SEX/DURATION :
female 6 week(s) pre-mating – 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – behavioral Reproductive – Effects on Newborn – physical
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1763 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception lactating female 1-21 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – biochemical and metabolic Reproductive – Effects on Newborn – behavioral
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1155 mg/kg
SEX/DURATION :
lactating female 21 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – growth statistics (e.g.%, reduced weight gain) Reproductive – Effects on Newborn – other postnatal measures or effects

MUTATION DATA

TEST SYSTEM :
Rodent – mouse
REFERENCE :
ARGEAR Archiv fuer Geschwulstforschung. (VEB Verlag Volk und Gesundheit Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1949- Volume(issue)/page/year: 51,605,1981 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 1,40,1972 TOXICOLOGY REVIEW FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 9,105,1971 TOXICOLOGY REVIEW ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967- Volume(issue)/page/year: 13,36,1977 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO LEAD, INORGANIC-air:10H TWA <0.1 mg(Pb)/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – X5250 No. of Facilities: 95 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 845 (estimated) No. of Female Employees: 433 (estimated)

Synonyms

EINECS 206-104-4
Lead acetate trihydrate
lead(2+),diacetate,trihydrate
MFCD00212528

 

 


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