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Big discounting Ropivacaine - 7361-61-7, Xylazine – Dumi

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Big discounting Ropivacaine - 7361-61-7, Xylazine – Dumi Detail:

Names

Name N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Synonym More Synonyms

 Xylazine Biological Activity

Description Xylazine is α2 class of adrenergic receptor agonist.Target: Adrenergic ReceptorXylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence). We concluded that xylazine given by epidural injection results in safe, effective perineal analgesia in horses [2].
Related Catalog
References

[1]. Reyes, J.C., et al., The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico. J Urban Health, 2012. 89(3): p. 519-26.

[2]. Hsu, W.H., Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents. J Pharmacol Exp Ther, 1981. 218(1): p. 188-92.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 334.2±52.0 °C at 760 mmHg
Melting Point 140ºC
Molecular Formula C12H16N2S
Molecular Weight 220.334
Flash Point 155.9±30.7 °C
Exact Mass 220.103424
PSA 49.69000
LogP 2.37
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.611
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ0776300
CHEMICAL NAME :
4H-1,3-Thiazine, 5,6-dihydro-2-(2,6-xylidino)-
CAS REGISTRY NUMBER :
7361-61-7
LAST UPDATED :
199606
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H16-N2-S
MOLECULAR WEIGHT :
220.36
WISWESSER LINE NOTATION :
T6N CS AUTJ BMR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human – woman
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Behavioral – somnolence (general depressed activity) Behavioral – changes in motor activity (specific assay) Cardiac – pulse rate
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 18,663,1981
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human – woman
DOSE/DURATION :
734 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) – miosis (pupillary constriction) Cardiac – pulse rate Vascular – BP lowering not characterized in autonomic section
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 4,222,1986
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human – woman
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Behavioral – somnolence (general depressed activity) Cardiac – pulse rate Lungs, Thorax, or Respiration – pleural thickening
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 4,222,1986
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 75,565,1968
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 75,565,1968
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
121 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 75,565,1968
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#10054 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – E0475 No. of Facilities: 403 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4029 (estimated) No. of Female Employees: 2015 (estimated)

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements Missing Phrase – N15.00950417
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R25
Safety Phrases S45
RIDADR UN 2811
WGK Germany 3
RTECS XJ0776300
Packaging Group III
Hazard Class 6.1
HS Code 2934999090

 Synthetic Route

Total: 1 Page

2,6-xylidine structure

2,6-xylidine

CAS#:87-62-7

~82%

 

Xylazine Structure

Xylazine

CAS#:7361-61-7

Literature: Vetamix Patent: US4614798 A1, 1986 ;
2-Isothiocyanato-1,3-dimethylbenzene structure

2-Isothiocyanat…

CAS#:19241-16-8

3-Aminopropan-1-ol structure

3-Aminopropan-1-ol

CAS#:156-87-6

~79%

 

Xylazine Structure

Xylazine

CAS#:7361-61-7

Literature: Vetamix Patent: US4614798 A1, 1986 ;

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles843

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Protective effects of glucosamine on oxidative-stress and ischemia/reperfusion-induced retinal injury.

Invest. Ophthalmol. Vis. Sci. 56(3) , 1506-16, (2015)

To investigate the protective effects of glucosamine (GlcN) using oxidative stress and rat models of ischemia-reperfusion (I/R) injury and to determine the antiapoptotic and anti-inflammatory mechanis…

Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks.

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Adipose-derived regenerative and stem cells, defined collectively as the stromal vascular fraction (SVF), support the formation of neovascular networks at the site of implantation. The effect of advan…

Enhanced Retinal Ganglion Cell Survival in Glaucoma by Hypoxic Postconditioning After Disease Onset.

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The neuroprotective efficacy of adaptive epigenetics, wherein beneficial gene expression changes are induced by nonharmful “conditioning” stimuli, is now well established in several acute, preclinical…

 Synonyms

Rompun
Xylazinum
xylazine
MFCD00057908
Xilazina [INN-Spanish]
EINECS 230-902-1
4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-
UNII-2KFG9TP5V8
N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Xylazinum [INN-Latin]
Xylazin
Xilazina
(5,6-dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-amine

 

 

 

 

 

Names

Name N-(2,6-dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Synonym More Synonyms

 Xylazine Biological Activity

Description Xylazine is α2 class of adrenergic receptor agonist.Target: Adrenergic ReceptorXylazine is a drug that is used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle and other non-human mammals. An analogue of clonidine, it is an agonist at the α2 class of adrenergic receptor. Xylazine has recently emerged as a recreational drug, especially in Puerto Rico [1]. Administration of xylazine (0.17 mg/kg of body weight, diluted to a 10-ml volume, using 0.9% NaCl) induced approximately 2.5 hours of local analgesia without apparent side effects. Higher doses of xylazine caused mild hind limb ataxia. Administration of lidocaine induced a similar duration of analgesia, with severe hind limb ataxia (100% incidence). We concluded that xylazine given by epidural injection results in safe, effective perineal analgesia in horses [2].
Related Catalog
References

[1]. Reyes, J.C., et al., The emerging of xylazine as a new drug of abuse and its health consequences among drug users in Puerto Rico. J Urban Health, 2012. 89(3): p. 519-26.

[2]. Hsu, W.H., Xylazine-induced depression and its antagonism by alpha adrenergic blocking agents. J Pharmacol Exp Ther, 1981. 218(1): p. 188-92.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 334.2±52.0 °C at 760 mmHg
Melting Point 140ºC
Molecular Formula C12H16N2S
Molecular Weight 220.334
Flash Point 155.9±30.7 °C
Exact Mass 220.103424
PSA 49.69000
LogP 2.37
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.611
Storage condition −20°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ0776300
CHEMICAL NAME :
4H-1,3-Thiazine, 5,6-dihydro-2-(2,6-xylidino)-
CAS REGISTRY NUMBER :
7361-61-7
LAST UPDATED :
199606
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C12-H16-N2-S
MOLECULAR WEIGHT :
220.36
WISWESSER LINE NOTATION :
T6N CS AUTJ BMR B1 F1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human – woman
DOSE/DURATION :
8 mg/kg
TOXIC EFFECTS :
Behavioral – somnolence (general depressed activity) Behavioral – changes in motor activity (specific assay) Cardiac – pulse rate
REFERENCE :
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW. Volume(issue)/page/year: 18,663,1981
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human – woman
DOSE/DURATION :
734 ug/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) – miosis (pupillary constriction) Cardiac – pulse rate Vascular – BP lowering not characterized in autonomic section
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 4,222,1986
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Human – woman
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Behavioral – somnolence (general depressed activity) Cardiac – pulse rate Lungs, Thorax, or Respiration – pleural thickening
REFERENCE :
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 4,222,1986
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
130 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 75,565,1968
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
240 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 75,565,1968
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
121 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 75,565,1968
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
18 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#10054 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – E0475 No. of Facilities: 403 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 4029 (estimated) No. of Female Employees: 2015 (estimated)

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements Missing Phrase – N15.00950417
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T:Toxic;
Risk Phrases R25
Safety Phrases S45
RIDADR UN 2811
WGK Germany 3
RTECS XJ0776300
Packaging Group III
Hazard Class 6.1
HS Code 2934999090

 Synthetic Route

Total: 1 Page

2,6-xylidine structure

2,6-xylidine

CAS#:87-62-7

~82%

 

Xylazine Structure

Xylazine

CAS#:7361-61-7

Literature: Vetamix Patent: US4614798 A1, 1986 ;
2-Isothiocyanato-1,3-dimethylbenzene structure

2-Isothiocyanat…

CAS#:19241-16-8

3-Aminopropan-1-ol structure

3-Aminopropan-1-ol

CAS#:156-87-6

~79%

 

Xylazine Structure

Xylazine

CAS#:7361-61-7

Literature: Vetamix Patent: US4614798 A1, 1986 ;

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles843

More Articles

Protective effects of glucosamine on oxidative-stress and ischemia/reperfusion-induced retinal injury.

Invest. Ophthalmol. Vis. Sci. 56(3) , 1506-16, (2015)

To investigate the protective effects of glucosamine (GlcN) using oxidative stress and rat models of ischemia-reperfusion (I/R) injury and to determine the antiapoptotic and anti-inflammatory mechanis…

Adipose-derived stromal vascular fraction cells isolated from old animals exhibit reduced capacity to support the formation of microvascular networks.

Exp. Gerontol. 63 , 18-26, (2015)

Adipose-derived regenerative and stem cells, defined collectively as the stromal vascular fraction (SVF), support the formation of neovascular networks at the site of implantation. The effect of advan…

Enhanced Retinal Ganglion Cell Survival in Glaucoma by Hypoxic Postconditioning After Disease Onset.

Neurotherapeutics 12(2) , 502-14, (2015)

The neuroprotective efficacy of adaptive epigenetics, wherein beneficial gene expression changes are induced by nonharmful “conditioning” stimuli, is now well established in several acute, preclinical…

 Synonyms

Rompun
Xylazinum
xylazine
MFCD00057908
Xilazina [INN-Spanish]
EINECS 230-902-1
4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-
UNII-2KFG9TP5V8
N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
Xylazinum [INN-Latin]
Xylazin
Xilazina
(5,6-dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-phenyl)-amine

Product detail pictures:

Big discounting Ropivacaine - 7361-61-7, Xylazine – Dumi detail pictures

Big discounting Ropivacaine - 7361-61-7, Xylazine – Dumi detail pictures


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We not only will try our greatest to offer you excellent services to each individual client, but also are ready to receive any suggestion offered by our buyers for Big discounting Ropivacaine - 7361-61-7, Xylazine – Dumi , The product will supply to all over the world, such as: Pakistan, Sierra Leone, New York, We insist on the principle of "Credit being primary, Customers being the king and Quality being the best", we are looking forward to the mutual cooperation with all friends at home and abroad and we will create a bright future of business.

contact us:

skype/wechat/whatsapp +8617172178855, +8617172178866
e-mail:victoria@chinadumi.com,aimee@chinadumi.com

 

 

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gfhdfh (2)

 

Why Choose US?
1. Selecting raw materials strictly,our products are the highest purity.
2.Reasonable and competitive price. Provide the best and professional service.
3.Fast delivery of the samples ,samples from stock. Reliable shipping way.
4.Full experience of large numbers containers loading in Chinese sea port.
5. Best after-service after shipment .
6. Professional documents for your custom clearance.

 

FAQ:
Q1:Will you supply samples for testing?
A: Free samples for the quality evaluation for most products, but customers only need to undertake the shipping fee for delivery the samples to your door.

Q2:What’s your MOQ?
A: For the high value product, our MOQ starts from 10g,100g and 1kg.

Q3:Which kind of payment terms do you accept?
A: Western Union, Corporate account, BTC, etc

Q4:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.

Q5:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

  • Superb technology, perfect after-sales service and efficient work efficiency, we think this is our best choice.
    5 Stars By Genevieve from Swaziland - 2018.05.15 10:52
    We feel easy to cooperate with this company, the supplier is very responsible, thanks.There will be more in-depth cooperation.
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