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Manufacturing Companies for Lidocaine - 128-44-9, Sodium Saccharin – Dumi

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Manufacturing Companies for Lidocaine - 128-44-9, Sodium Saccharin – Dumi Detail:

Names

Name o-Benzoic Sulfimide Sodium Salt
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 438.9ºC at 760 mmHg
Melting Point >300°C
Molecular Formula C7H4NNaO3S
Molecular Weight 205.166
Flash Point 219.3ºC
Exact Mass 204.980957
PSA 77.94000
LogP 1.08240
Vapour Pressure 1.77E-08mmHg at 25°C
Storage condition 0-6°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility >=10 g/100 mL at 20 ºC

 MSDS

Name: Saccharin Sodium Material Safety Data Sheet
Synonym: Sodium saccharin; 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt; Saccharin, sodium salt; Saccharin soluble
CAS: 128-44-9

Section 1 – Chemical Product MSDS Name:Saccharin Sodium Material Safety Data Sheet
Synonym:Sodium saccharin; 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt; Saccharin, sodium salt; Saccharin soluble


Section 2 – COMPOSITION, INFORMATION ON INGREDIENTS

CAS# Chemical Name content EINECS#
128-44-9 Sodium saccharin 100 204-886-1

Hazard Symbols: None Listed.
Risk Phrases: None Listed.


Section 3 – HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
Low hazard for usual industrial handling.
Ingestion:
The toxicological properties of this substance have not been fully investigated.
Inhalation:
Inhalation of dust may cause respiratory tract irritation.
Chronic:
Several studies in rats & mice have linked sodium saccharin to bladder tumors, but the mechanism believed to induce cancer in those animals does not appear to occur in humans. Rats & mice have a different urinary pH than do humans.


Section 4 – FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
Get medical aid if irritation or symptoms occur.
Inhalation:
Remove from exposure and move to fresh air immediately. Get medical aid if cough or other symptoms appear.
Notes to Physician:


Section 5 – FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.


Section 6 – ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.


Section 7 – HANDLING and STORAGE
Handling:
Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.


Section 8 – EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Good general ventilation should be sufficient to control airborne levels.
Exposure Limits CAS# 128-44-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA’s eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.


Section 9 – PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Freely Soluble.
Specific Gravity/Density: Not available.
Molecular Formula: C7H4O3NSNa
Molecular Weight: 205.17


Section 10 – STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide, toxic fumes of sodium oxide.
Hazardous Polymerization: Has not been reported.


Section 11 – TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 128-44-9: DE4550000 LD50/LC50:
CAS# 128-44-9: Oral, mouse: LD50 = 17500 mg/kg; Oral, rat: LD50 = 14200 mg/kg.
Carcinogenicity:
Sodium saccharin – Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.


Section 12 – ECOLOGICAL INFORMATION
Ecotoxicity:
The product is chemically identical to the natural amino acid L-Serine and can therefore can be degraded microbiologically.


Section 13 – DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.


Section 14 – TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:


Section 15 – REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 128-44-9: 0
Canada
CAS# 128-44-9 is listed on Canada’s DSL List.
CAS# 128-44-9 is not listed on Canada’s Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 128-44-9 is listed on the TSCA inventory.


SECTION 16 – ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE4550000
CHEMICAL NAME :
1,2-Benzisothiazolin-3-one, 1,1-dioxide, sodium salt
CAS REGISTRY NUMBER :
128-44-9
LAST UPDATED :
199806
DATA ITEMS CITED :
57
MOLECULAR FORMULA :
C7-H4-N-O3-S.Na
MOLECULAR WEIGHT :
205.17
WISWESSER LINE NOTATION :
T56 BSWMVJ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
14200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
7100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
17500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo – Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo – Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rabbit
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
756 gm/kg/36W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder – other changes in urine composition Kidney, Ureter, Bladder – other changes Nutritional and Gross Metabolic – weight loss or decreased weight gain
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
32400 mg/kg/54D-C
TOXIC EFFECTS :
Immunological Including Allergic – decrease in humoral immune response
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1092 gm/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic – Carcinogenic by RTECS criteria Kidney, Ureter, Bladder – tumors
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
176 mg/kg
TOXIC EFFECTS :
Tumorigenic – neoplastic by RTECS criteria Kidney, Ureter, Bladder – tumors Tumorigenic – tumors at site of application
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
112 gm/kg/8W-C
TOXIC EFFECTS :
Tumorigenic – neoplastic by RTECS criteria Kidney, Ureter, Bladder – Kidney tumors Skin and Appendages – tumors
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
224 gm/kg/8W-C
TOXIC EFFECTS :
Tumorigenic – neoplastic by RTECS criteria Kidney, Ureter, Bladder – Kidney tumors Skin and Appendages – tumors
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1330 gm/kg/95W-C
TOXIC EFFECTS :
Tumorigenic – equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder – tumors
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
2660 gm/kg/95W-C
TOXIC EFFECTS :
Tumorigenic – equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder – tumors Kidney, Ureter, Bladder – changes in blood vessels or in circulation of kidney
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1428 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic – equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder – tumors Kidney, Ureter, Bladder – changes in blood vessels or in circulation of kidney
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1190 gm/kg/85W-C
TOXIC EFFECTS :
Tumorigenic – equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder – Kidney tumors Kidney, Ureter, Bladder – changes in blood vessels or in circulation of kidney
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1827 gm/kg/87W-C
TOXIC EFFECTS :
Tumorigenic – Carcinogenic by RTECS criteria Kidney, Ureter, Bladder – tumors
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15 gm/kg
SEX/DURATION :
lactating female 15-21 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
325 gm/kg
SEX/DURATION :
male 4 week(s) pre-mating female 4 week(s) pre-mating – 4 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
103 gm/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive – Effects on Embryo or Fetus – fetal death
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive – Fertility – male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
2 gm/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive – Fertility – male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent – hamster Lung
DOSE/DURATION :
1 gm/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947- Volume(issue)/page/year: 70,271,1972 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,111,1980 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,334,1987 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 25,173,1978 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS – National Occupational Hazard Survey (1974) NOHS Hazard Code – 80527 No. of Facilities: 2086 (estimated) No. of Industries: 17 No. of Occupations: 22 No. of Employees: 13433 (estimated) NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – X8578 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1150 (estimated) No. of Female Employees: 591 (estimated) NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – 80527 No. of Facilities: 1735 (estimated) No. of Industries: 18 No. of Occupations: 44 No. of Employees: 67252 (estimated) No. of Female Employees: 49525 (estimated)

 Safety Information

Safety Phrases S24/25
WGK Germany 2
RTECS DE4550000
HS Code 2925110000

 Synthetic Route

Total: 1 Page

Saccharin structure

Saccharin

CAS#:81-07-2

~%

 

Sodium Saccharin Structure

Sodium Saccharin

CAS#:128-44-9

Literature: US5374738 A1, ;

 Customs

HS Code 2925110000
Summary HS: 2925110000. benzo[d]isothiazol-3(2h)-one 1,1-dioxide. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:9.0%. general tariff:90.0%

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 Synonyms

1,2-benzisothiazol-3-ol, 1,1-dioxide, sodium salt (1:1)
1,2-Benzisothiazol-3(2H)-one 1,1-dioxide sodium salt
Saccharin sodium
o-SulfobenziMide SodiuM Salt Dihydrate
EINECS 204-886-1
MFCD00013092
Sodium o-Sulfobenzimide
Saccharin sodium salt
Sucaryl
ODA
1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt (1:1)
Sucredulcor
Sodium 3-oxo-3H-1,2-benzothiazol-2-ide 1,1-dioxide
Saccharin sodium salt,Saccharin sodium
Sodium 3-oxo-3H-benzo[d]isothiazol-2-ide 1,1-dioxide
1,1-Dioxide-1,2-benzisothiazol-3(2H)-one Sodium Salt
o-Benzoylsulfimide Sodium Salt
Sodium Saccharin

 

 

 

Names

Name o-Benzoic Sulfimide Sodium Salt
Synonym More Synonyms

 Chemical & Physical Properties

Boiling Point 438.9ºC at 760 mmHg
Melting Point >300°C
Molecular Formula C7H4NNaO3S
Molecular Weight 205.166
Flash Point 219.3ºC
Exact Mass 204.980957
PSA 77.94000
LogP 1.08240
Vapour Pressure 1.77E-08mmHg at 25°C
Storage condition 0-6°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility >=10 g/100 mL at 20 ºC

 MSDS

Name: Saccharin Sodium Material Safety Data Sheet
Synonym: Sodium saccharin; 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt; Saccharin, sodium salt; Saccharin soluble
CAS: 128-44-9

Section 1 – Chemical Product MSDS Name:Saccharin Sodium Material Safety Data Sheet
Synonym:Sodium saccharin; 1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt; Saccharin, sodium salt; Saccharin soluble


Section 2 – COMPOSITION, INFORMATION ON INGREDIENTS

CAS# Chemical Name content EINECS#
128-44-9 Sodium saccharin 100 204-886-1

Hazard Symbols: None Listed.
Risk Phrases: None Listed.


Section 3 – HAZARDS IDENTIFICATION

EMERGENCY OVERVIEW
Not available.
Potential Health Effects
Eye:
May cause eye irritation.
Skin:
Low hazard for usual industrial handling.
Ingestion:
The toxicological properties of this substance have not been fully investigated.
Inhalation:
Inhalation of dust may cause respiratory tract irritation.
Chronic:
Several studies in rats & mice have linked sodium saccharin to bladder tumors, but the mechanism believed to induce cancer in those animals does not appear to occur in humans. Rats & mice have a different urinary pH than do humans.


Section 4 – FIRST AID MEASURES
Eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical aid if irritation develops or persists.
Ingestion:
Get medical aid if irritation or symptoms occur.
Inhalation:
Remove from exposure and move to fresh air immediately. Get medical aid if cough or other symptoms appear.
Notes to Physician:


Section 5 – FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.


Section 6 – ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Avoid generating dusty conditions. Provide ventilation.


Section 7 – HANDLING and STORAGE
Handling:
Use with adequate ventilation. Minimize dust generation and accumulation. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage:
Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.


Section 8 – EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Good general ventilation should be sufficient to control airborne levels.
Exposure Limits CAS# 128-44-9: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA’s eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to minimize contact with skin.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.


Section 9 – PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Solid
Color: white
Odor: none reported
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: Not available.
Autoignition Temperature: Not applicable.
Flash Point: Not applicable.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature: Not available.
Solubility in water: Freely Soluble.
Specific Gravity/Density: Not available.
Molecular Formula: C7H4O3NSNa
Molecular Weight: 205.17


Section 10 – STABILITY AND REACTIVITY
Chemical Stability:
Stable under normal temperatures and pressures.
Conditions to Avoid:
Dust generation.
Incompatibilities with Other Materials:
Strong oxidizing agents.
Hazardous Decomposition Products:
Nitrogen oxides, carbon monoxide, oxides of sulfur, carbon dioxide, toxic fumes of sodium oxide.
Hazardous Polymerization: Has not been reported.


Section 11 – TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 128-44-9: DE4550000 LD50/LC50:
CAS# 128-44-9: Oral, mouse: LD50 = 17500 mg/kg; Oral, rat: LD50 = 14200 mg/kg.
Carcinogenicity:
Sodium saccharin – Not listed by ACGIH, IARC, or NTP.
Other:
See actual entry in RTECS for complete information.


Section 12 – ECOLOGICAL INFORMATION
Ecotoxicity:
The product is chemically identical to the natural amino acid L-Serine and can therefore can be degraded microbiologically.


Section 13 – DISPOSAL CONSIDERATIONS
Products which are considered hazardous for supply are classified as Special Waste and the disposal of such chemicals is covered by regulations which may vary according to location. Contact a specialist disposal company or the local waste regulator for advice. Empty containers must be decontaminated before returning for recycling.


Section 14 – TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing group:


Section 15 – REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: Not available.
Risk Phrases:
Safety Phrases:
WGK (Water Danger/Protection)
CAS# 128-44-9: 0
Canada
CAS# 128-44-9 is listed on Canada’s DSL List.
CAS# 128-44-9 is not listed on Canada’s Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 128-44-9 is listed on the TSCA inventory.


SECTION 16 – ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DE4550000
CHEMICAL NAME :
1,2-Benzisothiazolin-3-one, 1,1-dioxide, sodium salt
CAS REGISTRY NUMBER :
128-44-9
LAST UPDATED :
199806
DATA ITEMS CITED :
57
MOLECULAR FORMULA :
C7-H4-N-O3-S.Na
MOLECULAR WEIGHT :
205.17
WISWESSER LINE NOTATION :
T56 BSWMVJ &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
14200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
7100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
17500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 – Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo – Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
7 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo – Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rabbit
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
756 gm/kg/36W-C
TOXIC EFFECTS :
Kidney, Ureter, Bladder – other changes in urine composition Kidney, Ureter, Bladder – other changes Nutritional and Gross Metabolic – weight loss or decreased weight gain
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
32400 mg/kg/54D-C
TOXIC EFFECTS :
Immunological Including Allergic – decrease in humoral immune response
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1092 gm/kg/1Y-C
TOXIC EFFECTS :
Tumorigenic – Carcinogenic by RTECS criteria Kidney, Ureter, Bladder – tumors
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Implant
SPECIES OBSERVED :
Rodent – mouse
DOSE/DURATION :
176 mg/kg
TOXIC EFFECTS :
Tumorigenic – neoplastic by RTECS criteria Kidney, Ureter, Bladder – tumors Tumorigenic – tumors at site of application
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
112 gm/kg/8W-C
TOXIC EFFECTS :
Tumorigenic – neoplastic by RTECS criteria Kidney, Ureter, Bladder – Kidney tumors Skin and Appendages – tumors
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
224 gm/kg/8W-C
TOXIC EFFECTS :
Tumorigenic – neoplastic by RTECS criteria Kidney, Ureter, Bladder – Kidney tumors Skin and Appendages – tumors
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1330 gm/kg/95W-C
TOXIC EFFECTS :
Tumorigenic – equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder – tumors
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
2660 gm/kg/95W-C
TOXIC EFFECTS :
Tumorigenic – equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder – tumors Kidney, Ureter, Bladder – changes in blood vessels or in circulation of kidney
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1428 gm/kg/2Y-C
TOXIC EFFECTS :
Tumorigenic – equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder – tumors Kidney, Ureter, Bladder – changes in blood vessels or in circulation of kidney
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1190 gm/kg/85W-C
TOXIC EFFECTS :
Tumorigenic – equivocal tumorigenic agent by RTECS criteria Kidney, Ureter, Bladder – Kidney tumors Kidney, Ureter, Bladder – changes in blood vessels or in circulation of kidney
TYPE OF TEST :
TD – Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent – rat
DOSE/DURATION :
1827 gm/kg/87W-C
TOXIC EFFECTS :
Tumorigenic – Carcinogenic by RTECS criteria Kidney, Ureter, Bladder – tumors
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
15 gm/kg
SEX/DURATION :
lactating female 15-21 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
325 gm/kg
SEX/DURATION :
male 4 week(s) pre-mating female 4 week(s) pre-mating – 4 day(s) post-birth
TOXIC EFFECTS :
Reproductive – Effects on Newborn – growth statistics (e.g.%, reduced weight gain)
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
103 gm/kg
SEX/DURATION :
male 30 day(s) pre-mating
TOXIC EFFECTS :
Reproductive – Effects on Embryo or Fetus – fetal death
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
2 gm/kg
SEX/DURATION :
multigenerations
TOXIC EFFECTS :
Reproductive – Fertility – male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
TDLo – Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
DOSE :
2 gm/kg
SEX/DURATION :
male 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive – Fertility – male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Unscheduled DNA synthesis
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Cytogenetic analysis
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST :
Dominant lethal test
TYPE OF TEST :
Sperm Morphology

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent – hamster Lung
DOSE/DURATION :
1 gm/L
REFERENCE :
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947- Volume(issue)/page/year: 70,271,1972 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 22,111,1980 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,334,1987 TOXICOLOGY REVIEW AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960- Volume(issue)/page/year: 23,6,1971 TOXICOLOGY REVIEW EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972- Volume(issue)/page/year: 25,173,1978 TOXICOLOGY REVIEW BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973- Volume(issue)/page/year: 24,253,1983 TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS – National Occupational Hazard Survey (1974) NOHS Hazard Code – 80527 No. of Facilities: 2086 (estimated) No. of Industries: 17 No. of Occupations: 22 No. of Employees: 13433 (estimated) NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – X8578 No. of Facilities: 11 (estimated) No. of Industries: 1 No. of Occupations: 5 No. of Employees: 1150 (estimated) No. of Female Employees: 591 (estimated) NOES – National Occupational Exposure Survey (1983) NOES Hazard Code – 80527 No. of Facilities: 1735 (estimated) No. of Industries: 18 No. of Occupations: 44 No. of Employees: 67252 (estimated) No. of Female Employees: 49525 (estimated)

 Safety Information

Safety Phrases S24/25
WGK Germany 2
RTECS DE4550000
HS Code 2925110000

 Synthetic Route

Total: 1 Page

Saccharin structure

Saccharin

CAS#:81-07-2

~%

 

Sodium Saccharin Structure

Sodium Saccharin

CAS#:128-44-9

Literature: US5374738 A1, ;

 Customs

HS Code 2925110000
Summary HS: 2925110000. benzo[d]isothiazol-3(2h)-one 1,1-dioxide. VAT:17.0%. tax rebate rate:9.0%. supervision conditions:ab(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tarrif:9.0%. general tariff:90.0%

 Articles3

More Articles

Fructose- and glucose-conditioned preferences in FVB mice: strain differences in post-oral sugar appetition.

Am. J. Physiol. Regul. Integr. Comp. Physiol. 307(12) , R1448-57, (2014)

Recent studies indicate that, unlike glucose, fructose has little or no post-oral preference conditioning actions in C57BL/6J (B6) mice. The present study determined whether this is also the case for …

3,4-Methylenedioxypyrovalerone (MDPV)-induced conditioned taste avoidance in the F344/N and LEW rat strains.

Pharmacol. Biochem. Behav. 126 , 163-9, (2014)

The inbred Fischer (F344) and Lewis (LEW) rats, while originally developed as animal models for cancer and tissue transplantation research, have since been used to study genetic differences in a varie…

Masking the bitter taste of injectable lidocaine HCl formulation for dental procedures.

AAPS PharmSciTech 16(2) , 455-65, (2015)

Several attempts have been made to mask the bitter taste of oral formulations, but none have been made for injectable formulations. This study aims to mask the bitter taste of dental lidocaine HCl (LI…

 Synonyms

1,2-benzisothiazol-3-ol, 1,1-dioxide, sodium salt (1:1)
1,2-Benzisothiazol-3(2H)-one 1,1-dioxide sodium salt
Saccharin sodium
o-SulfobenziMide SodiuM Salt Dihydrate
EINECS 204-886-1
MFCD00013092
Sodium o-Sulfobenzimide
Saccharin sodium salt
Sucaryl
ODA
1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide, sodium salt (1:1)
Sucredulcor
Sodium 3-oxo-3H-1,2-benzothiazol-2-ide 1,1-dioxide
Saccharin sodium salt,Saccharin sodium
Sodium 3-oxo-3H-benzo[d]isothiazol-2-ide 1,1-dioxide
1,1-Dioxide-1,2-benzisothiazol-3(2H)-one Sodium Salt
o-Benzoylsulfimide Sodium Salt
Sodium Saccharin

Product detail pictures:

Manufacturing Companies for Lidocaine - 128-44-9, Sodium Saccharin – Dumi detail pictures

Manufacturing Companies for Lidocaine - 128-44-9, Sodium Saccharin – Dumi detail pictures


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we are able to provide good quality items, aggressive rate and best shopper assistance. Our destination is "You come here with difficulty and we provide you with a smile to take away" for Manufacturing Companies for Lidocaine - 128-44-9, Sodium Saccharin – Dumi , The product will supply to all over the world, such as: Philippines, Estonia, Barbados, Our items have national accreditation requirements for qualified, high quality products, affordable value, was welcomed by people today all over the world. Our goods will continue to enhance within the order and look forward to cooperation with you, Should any of these products be of interest to you, please letus know. We are going to be content to offer you a quotation up on receipt of your detailed needs.

contact us:

skype/wechat/whatsapp :+8617172178866
e-mail:victoria@chinadumi.com

 

 

Packing

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Why Choose US?
1. Selecting raw materials strictly,our products are the highest purity.
2.Reasonable and competitive price. Provide the best and professional service.
3.Fast delivery of the samples ,samples from stock. Reliable shipping way.
4.Full experience of large numbers containers loading in Chinese sea port.
5. Best after-service after shipment .
6. Professional documents for your custom clearance.

 

FAQ:
Q1:Will you supply samples for testing?
A: Free samples for the quality evaluation for most products, but customers only need to undertake the shipping fee for delivery the samples to your door.

Q2:What’s your MOQ?
A: For the high value product, our MOQ starts from 10g,100g and 1kg.

Q3:Which kind of payment terms do you accept?
A: Western Union, Corporate account, BTC, etc

Q4:How about your delivery time?
A: Generally, it will take 3 to 5 days after receiving your advance payment.

Q5:How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

  • Timely delivery, strict implementation of the contract provisions of the goods, encountered special circumstances, but also actively cooperate, a trustworthy company!
    5 Stars By Evangeline from Hamburg - 2017.12.19 11:10
    This enterprise in the industry is strong and competitive, advancing with the times and develop sustainable, we are very pleased to have a opportunity to cooperate!
    5 Stars By Afra from Liverpool - 2017.03.28 12:22
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