professional factory for Procaine - 94-09-7, Benzocaine – Dumi
professional factory for Procaine - 94-09-7, Benzocaine – Dumi Detail:
Benzocaine Biological Activity
Description | Benzocaine shares a common receptor with all other local anesthetics (LAs) in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV. |
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Related Catalog | |
Target | IC50: 0.8 mM (Na+ channel)[1]. |
In Vitro | Benzocaine blocks μ1 wild-type Na+ currents in a dose-dependent Manner. The Benzocaine concentration that inhibits 50% of Na+ currents (IC50) is estimated to be about 0.8 mM when a test potential of +30 mV is applied. The slope of the h∞ curve is also significantly reduced by benzocaine (from 6.6 to 9.9 mV). Mutation of μ1-N1584A also significantly increases the potency of Benzocaine. At 1 mM, Benzocaine blocks about 55% of wild-type Na+ current but about 95% of μ1-N1584A mutant current. Benzocaine also appears to bind more strongly to its LA receptor in the N1584A mutant than in the wild type[1]. The inhibition of Ca2+ uptake occurres at lower Benzocaine concentration (IC50=40.3±1.2mM) than that affecting the enzymatic activity[2]. |
In Vivo | A common Benzocaine-containing anesthetic is topically applied to the following species: dogs, domestic shorthair cats, Long-Evans rats, Sprague-Dawley rats, ferrets, rhesus monkeys, cynomolgus monkeys, owl monkeys, New Zealand White rabbits, miniature pigs, ICR mice, C3H mice, and C57BL/10SnJ mice. All animals, except mice and rats, receive a 2-second spray to the mucous membranes of the nasopharynx for an estimated dose of 56 mg. A 2-second spray to rodents’ oral mucous membranes delivers too great a volume of fluid for these animals. The study is repeated in dogs several months later to confirm low response. Response to Benzocaine spray is observed in most animals tested, with response peaking between 15 and 30 minutes after dosing[3]. |
References | [1]. Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435(2):293-302. |
Chemical & Physical Properties
Density | 1.1±0.1 g/cm3 |
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Boiling Point | 310.7±15.0 °C at 760 mmHg |
Melting Point | 88-90 °C |
Molecular Formula | C9H11NO2 |
Molecular Weight | 165.189 |
Flash Point | 164.2±17.9 °C |
Exact Mass | 165.078979 |
PSA | 52.32000 |
LogP | 1.95 |
Vapour Pressure | 0.0±0.7 mmHg at 25°C |
Index of Refraction | 1.555 |
Storage condition | 0-6°C |
Stability | Stable. Combustible. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Safety Information
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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Hazard Codes | Xi:Irritant |
Risk Phrases | R36/37/38;R43 |
Safety Phrases | 22-24/25-37/39-26-24 |
RIDADR | NONH for all modes of transport |
WGK Germany | 2 |
RTECS | DG2450000 |
Packaging Group | III |
HS Code | 2922499990 |
Synonyms
ORTHESIN |
Americaine |
Ora-jel |
ethyl 4-aminobenzene carboxylate |
Anaesthesin |
AETHOFORM |
Benzocainum |
Ethyl 4-aminobenzoate |
ethyl ester of p-aminobenzoic acid |
Benzocaine |
Ethoform |
4-Aminobenzoic acid ethyl ester |
Topcaine |
Benzoic acid, 4-amino-, ethyl ester |
Solu H |
MFCD00007892 |
Euphagin |
EINECS 202-303-5 |
4-ethoxycarbonylaniline |
Norcaine |
4-amino-benzoic acid ethyl ester |
Norcain |
Anaesthin |
Anbesol |
ethyl 4-amino-benzoate |
p-aminobenzoic acid ethyl ester |
Ethyl4-aminobenzoate |
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To get the stage of realizing dreams of our employees! To build a happier, more united and much more skilled crew! To reach a mutual benefit of our prospects, suppliers, the society and ourselves for professional factory for Procaine - 94-09-7, Benzocaine – Dumi , The product will supply to all over the world, such as: Ghana, Portland, Algeria, Our staffs are adhering to the "Integrity-based and Interactive Development" spirit, and the tenet of "First-class Quality with Excellent Service". According to the needs of every customer, we give customized & personalised services to help customers achieve their goals successfully. Welcome clients from home and abroad to call and inquire!
contact us:
skype/wechat/whatsapp :+8617172178866
e-mail:victoria@chinadumi.com
Packing
Why Choose US?
1. Selecting raw materials strictly,our products are the highest purity.
2.Reasonable and competitive price. Provide the best and professional service.
3.Fast delivery of the samples ,samples from stock. Reliable shipping way.
4.Full experience of large numbers containers loading in Chinese sea port.
5. Best after-service after shipment .
6. Professional documents for your custom clearance.
1.How can we guarantee quality?
Always a pre-production sample before mass production; Always final Inspection before shipment.
2.why should you buy from us ?
(1)High purity good quality with pretty competitive price. (2)Large capacity of stable products supply. (3)Safty and fast shipment by sea/by air. (4)Sample order acceptable.(5)Good and tight packing as customized.
3.What’s your MOQ? What is the time of shipment?
Normally,our MOQ is 1kg. But it could be according to your actual demand. Any quantity is OK.
Generally 2-3 days after receiving the payment (except Chinese holidays)
4.Is there a discount?
Of course, we will consider a discount for first time purchasers, even for large quantities.
5.what payment terms do you accept ? we’d like to accept bank transfer, Western Union or BTC.
By Maggie from Dubai - 2017.08.16 13:39
This supplier's raw material quality is stable and reliable, has always been in accordance with the requirements of our company to provide the goods that quality meet our requirements.
By Doreen from Swaziland - 2018.07.27 12:26